Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect multiple organs. In children, SLE is often more severe than in adults, and organ damage is a major cause of morbidity and mortality.
Methods
This study included 100 children with SLE who were followed for a median of 5 years. The researchers collected data on the patients’ clinical characteristics, laboratory findings, and organ damage. They then used statistical models to identify predictors of organ damage.
Results
The researchers found that several factors were associated with an increased risk of organ damage in children with SLE. These factors included:
- High levels of disease activity
- Presence of anti-double-stranded DNA (dsDNA) antibodies
- Low levels of complement C3
- History of lupus nephritis
- African American race
Discussion
The findings of this study suggest that several factors can help to predict organ damage in children with SLE. These factors can be used to identify patients who are at high risk of organ damage and who may need more aggressive treatment.
Conclusion
This study provides important new information about the predictors of organ damage in children with SLE. This information can be used to improve the care of these patients and to prevent organ damage.
Kind regards
J. Greer
Children’s health News & Trends
