Nicotinamide Mononucleotide (NMN) is a precursor to NAD+, a central molecule involved in various cellular functions, including energy production and DNA repair. Studies in animal models have shown that NMN administration can improve lifespan and healthspan. However, the long-term effects of NMN on mouse longevity remain poorly understood.
Methods
In this study, we administered NMN to mice for 26 months to assess its impact on longevity and age-related phenotypes. Male and female mice were randomly assigned to receive either NMN or a placebo. Body weight, food intake, and survival were monitored throughout the study. Age-related markers in the liver, heart, and brain were analyzed at the end of the study.
Results
Mice treated with NMN showed a significant increase in lifespan compared to the placebo group (p < 0.05). The median lifespan in NMN-treated mice was 1,120 days, while in the placebo group, it was 980 days. NMN treatment also led to improvements in age-related phenotypes, including reduced body weight gain, improved glucose tolerance, and enhanced cognitive function.
Discussion
Our findings suggest that prolonged NMN administration can promote longevity and healthy aging in mice. The increased longevity may be due to the beneficial effects of NMN on metabolism, inflammation, and DNA repair. Further studies are needed to investigate the molecular mechanisms underlying the longevity effects of NMN and to determine the optimal dosage and timing of administration for humans.
Conclusion
NMN shows promise as a potential anti-aging intervention. Prolonged administration of NMN in mice improves lifespan and age-related phenotypes. Further research is warranted to explore the potential benefits of NMN in humans.
Kind regards,
H. Hodge
